Gene
ctnnd1
- ID
- ZDB-GENE-110208-9
- Name
- catenin (cadherin-associated protein), delta 1
- Symbol
- ctnnd1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cadherin binding activity. Acts upstream of or within cell migration involved in gastrulation; mesodermal cell migration; and posterior lateral line neuromast primordium migration. Predicted to be located in cell junction. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Hsu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blepharocheilodontic syndrome 2 | Alliance | Blepharocheilodontic syndrome 2 | 617681 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Plakophilin/Delta catenin |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q693
|
875 | ||||
|
UniProtKB:A0A286Y8C1
|
931 | ||||
|
UniProtKB:A0A8M3AK93
|
914 | ||||
|
UniProtKB:A0A8M9PZY3
|
944 | ||||
|
UniProtKB:F1R6C8
|
908 |
1 - 5 of 6 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctnnd1-201
(1)
|
Ensembl | 4,796 nt | ||
| mRNA |
ctnnd1-202
(1)
|
Ensembl | 424 nt | ||
| mRNA |
ctnnd1-204
(1)
|
Ensembl | 552 nt | ||
| mRNA |
ctnnd1-205
(1)
|
Ensembl | 4,730 nt | ||
| mRNA |
ctnnd1-206
(1)
|
Ensembl | 539 nt |
1 - 5 of 8 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-59P5 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009293418 (1) | 5191 nt | ||
| Genomic | GenBank:CR848663 (1) | 193836 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q686 (1) | 950 aa |
- Kupai, A., Nakahara, H., Voss, K.M., Hirano, M.S., Rodriguez, A., Lackey, D.L., Murayama, J.F., Mathieson, C.J., Shan, B., Horton, E.C., Curtis, G.H., Huang, J., Hille, M.B. (2022) Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(12):1952-1967
- Shan, B., Horton, E.C., Xu, S.C., Huntington, K.E., Kawano, D.K., Mendoza, C.L., Lin, L., Stafford, C.M., Allen, E.D., Huang, J., Nakahara, H., Greenstein, L.E., Hille, M.B. (2022) Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(12):1934-1951
- DeLaurier, A., Howe, D.G., Ruzicka, L., Carte, A.N., Mishoe Hernandez, L., Wiggins, K.J., Gallati, M.M., Vanpelt, K., Loyo Rosado, F., Pugh, K.G., Shabdue, C.J., Jihad, K., Thyme, S.B., Talbot, J.C. (2021) ZebraShare: a new venue for rapid dissemination of zebrafish mutant data. PeerJ. 9:e11007
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Mizoguchi, T., Ikeda, S., Watanabe, S., Sugawara, M., Itoh, M. (2017) Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Proceedings of the National Academy of Sciences of the United States of America. 114(44):E9280-E9289
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lee, P.T., Zou, J., Holland, J.W., Martin, S.A., Scott, C.J., Kanellos, T., Secombes, C.J. (2015) Functional characterisation of a TLR accessory protein, UNC93B1, in Atlantic salmon (Salmo salar). Developmental and comparative immunology. 50(1):38-48
- Hsu, C.L., Muerdter, C.P., Knickerbocker, A.D., Walsh, R.M., Zepeda-Rivera, M.A., Depner, K.H., Sangesland, M., Cisneros, T.B., Kim, J.Y., Sanchez-Vazquez, P., Cherezova, L., Regan, R.D., Bahrami, N.M., Gray, E.A., Chan, A.Y., Chen, T., Rao, M.Y., and Hille, M.B. (2012) Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(10):1545-1561
1 - 8 of 8
Show