Gene
nup214
- ID
- ZDB-GENE-110203-3
- Name
- nucleoporin 214
- Symbol
- nup214 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within with a negative effect on Notch signaling pathway. Is expressed in several structures, including central nervous system; fertilized egg; gonad; heart; and immune system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kindermann et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kindermann et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, T-cell acute lymphoblastic, somatic | 613065 |
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| {Encephalopathy, acute, infection-induced, susceptibility to, 9} | 618426 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear pore complex protein | Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain | WD40 repeat | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z6M9
|
2055 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available