Gene
cyp2r1
- ID
- ZDB-GENE-110114-1
- Name
- cytochrome P450, family 2, subfamily R, polypeptide 1
- Symbol
- cyp2r1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within cellular response to vitamin D; hematopoietic stem cell proliferation; and vitamin D3 metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver; muscle; ovary; and visceral fat. Used to study vitamin D-dependent rickets type 1B. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb152 | Allele with one delins | Unknown | Premature Stop | TALEN | |
| ihb153 | Allele with one deletion | Unknown | Premature Stop | TALEN | |
| la029312Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029313Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7595 | Allele with one point mutation | Unknown | Missense | ENU | |
| zf734 | Allele with one deletion | Exon 3 | Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vitamin D-dependent rickets type 1B | Alliance | Rickets due to defect in vitamin D 25-hydroxylation deficiency | 600081 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitamin D-dependent rickets type 1B | cyp2r1zf734/zf734 | standard conditions | Cortes et al., 2015 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp2r1-201
(1)
|
Ensembl | 2,317 nt | ||
| mRNA |
cyp2r1-202
(1)
|
Ensembl | 886 nt | ||
| mRNA |
cyp2r1-203
(1)
|
Ensembl | 813 nt | ||
| ncRNA |
cyp2r1-003
(1)
|
Ensembl | 314 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79E4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-246O4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001386362 (1) | 2580 nt | ||
| Genomic | GenBank:AL954331 (1) | 174045 nt | ||
| Polypeptide | RefSeq:NP_001373291 (1) |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Liang, S., Zhang, H., Jiao, L., Shao, R., Lan, Y., Liao, X., Mai, K., Ai, Q., Wan, M. (2024) Vitamin D promotes the folate transport and metabolism in zebrafish (Danio rerio). American journal of physiology. Endocrinology and metabolism. 326(4):E482-E492
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Liao, X., Lan, Y., Shao, R., Liu, J., Liang, S., Yin, Z., Gudmundsson, G.H., Bergman, P., Wan, M. (2021) Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (Danio rerio). Journal of Innate Immunity. 14(3):229-242
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Pan, Y.X., Zhuo, M.Q., Li, D.D., Xu, Y.H., Wu, K., Luo, Z. (2018) SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Chemosphere. 215:370-379
- Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z. (2017) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3.. Cell Reports. 19:1444-1455
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