Gene

kcnma1b

ID
ZDB-GENE-101209-2
Name
potassium large conductance calcium-activated channel, subfamily M, alpha member 1b
Symbol
kcnma1b Nomenclature History
Previous Names
  • slo1b (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnma1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
paroxysmal nonkinesigenic dyskinesia 3 Alliance Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy 609446
Cerebellar atrophy, developmental delay, and seizures 617643
Liang-Wang syndrome 618729
{Epilepsy, idiopathic generalized, susceptibility to, 16} 618596
Associated With kcnma1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003929 Calcium-activated potassium channel BK, alpha subunit
Domain IPR005821 Ion transport domain
Domain IPR048735 Ca2+-activated K+ channel Slowpoke-like, C-terminal domain
Family IPR047871 Calcium-activated potassium channel slowpoke-like
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Ca2+-activated K+ channel Slowpoke-like, C-terminal domain Calcium-activated potassium channel BK, alpha subunit Calcium-activated potassium channel slowpoke-like Ion transport domain NAD(P)-binding domain superfamily
UniProtKB:A0A8M9PXE8 1107
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations