Gene
alkal2a
- ID
- ZDB-GENE-100922-116
- Name
- ALK and LTK ligand 2a
- Symbol
- alkal2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Acts upstream of or within iridophore differentiation. Predicted to be located in extracellular region. Orthologous to human ALKAL2 (ALK and LTK ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alkal2-202
(1)
|
Ensembl | 574 nt | ||
| mRNA |
alkal2a-202
(1)
|
Ensembl | 204 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-268M8 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423886 (1) | |||
| Genomic | GenBank:CU694248 (1) | 32791 nt | ||
| Polypeptide | RefSeq:NP_001410815 (1) |
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Fadeev, A., Mendoza-Garcia, P., Irion, U., Guan, J., Pfeifer, K., Wiessner, S., Serluca, F., Singh, A.P., Nüsslein-Volhard, C., Palmer, R.H. (2018) ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells. Proceedings of the National Academy of Sciences of the United States of America. 115(4):E630-E638
- Mo, E.S., Cheng, Q., Reshetnyak, A.V., Schlessinger, J., Nicoli, S. (2017) Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk. Proceedings of the National Academy of Sciences of the United States of America. 114(45):12027-12032
- Chatterjee, A., Lagisz, M., Rodger, E.J., Zhen, L., Stockwell, P.A., Duncan, E.J., Horsfield, J.A., Jeyakani, J., Mathavan, S., Ozaki, Y., Nakagawa, S. (2016) Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Gene. 590(2):307-16
1 - 4 of 4
Show