Gene
ptpn23a
- ID
- ZDB-GENE-100921-24
- Name
- protein tyrosine phosphatase, non-receptor type 23, a
- Symbol
- ptpn23a Nomenclature History
- Previous Names
-
- si:dkey-201i6.7
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in early endosome to late endosome transport; endocytic recycling; and protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in endosome. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from van Eekelen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity | 618890 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR004328 | BRO1 domain |
| Domain | IPR016103 | ProQ/FinO domain |
| Domain | IPR025304 | ALIX V-shaped domain |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR038499 | BRO1 domain superfamily |
Domain Details Per Protein
| Protein | Length | ALIX V-shaped domain | BRO1 domain | BRO1 domain superfamily | ProQ/FinO domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R1D1
|
1987 | |||||||||
|
UniProtKB:F1Q653
|
2003 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn23a-201
(1)
|
Ensembl | 6,714 nt | ||
| mRNA |
ptpn23a-202
(1)
|
Ensembl | 6,761 nt |
Interactions and Pathways
No data available
Plasmids
No data available