Gene
cyp17a2
- ID
- ZDB-GENE-100822-1
- Name
- cytochrome P450, family 17, subfamily A, polypeptide 2
- Symbol
- cyp17a2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within progesterone metabolic process. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014465Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022780Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zf3680 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A7U483
|
495 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp17a2-201
(1)
|
Ensembl | 1,488 nt | ||
| ncRNA |
cyp17a2-002
(1)
|
Ensembl | 341 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-290K24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105670 (1) | 1488 nt | ||
| Genomic | GenBank:CU681841 (1) | 100884 nt | ||
| Polypeptide | UniProtKB:A7U483 (1) | 495 aa |
No data available
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Shi, S., Shu, T., Li, X., Lou, Q., Jin, X., He, J., Yin, Z., Zhai, G. (2022) Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish. Frontiers in endocrinology. 13:910639
- Chen, Y., Tang, H., Wang, L., Wei, T., Liu, X., Lin, H. (2019) New insights into the role of mTORC1 in male fertility in zebrafish. General and comparative endocrinology. 286:113306
- Shang, G., Peng, X., Ji, C., Zhai, G., Ruan, Y., Lou, Q., Jin, X., He, J., Wang, H., Yin, Z. (2019) Star and LH are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of reproduction. 101(4):760-770
- Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
- Weger, M., Weger, B.D., Görling, B., Poschet, G., Yildiz, M., Hell, R., Luy, B., Akcay, T., Güran, T., Dickmeis, T., Müller, F., Krone, N. (2018) Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine. 36:376-389
- Eachus, H., Zaucker, A., Oakes, J.A., Griffin, A., Weger, M., Güran, T., Taylor, A., Harris, A., Greenfield, A., Quanson, J.L., Storbeck, K.H., Cunliffe, V.T., Müller, F., Krone, N. (2017) Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology. 158(12):4165-4173
- Gonzalez, E., Johnson, K.M., Pallan, P.S., Phan, T.T.N., Zhang, W., Lei, L.I., Wawrzak, Z., Yoshimoto, F.K., Egli, M., Guengerich, F.P. (2017) Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes. The Journal of biological chemistry. 293(2):541-556
- Tang, H., Chen, Y., Liu, Y., Yin, Y., Li, G., Guo, Y., Liu, X., Lin, H. (2017) New Insights Into the Role of Estrogens in Male Fertility Based on Findings in Aromatase-Deficient Zebrafish. Endocrinology. 158:3042-3054
- Tang, H., Chen, Y., Wang, L., Yin, Y., Li, G., Guo, Y., Liu, Y., Lin, H., Cheng, C.H.K., Liu, X. (2017) Fertility impairment with defective spermatogenesis and steroidogenesis in male zebrafish lacking androgen receptor. Biology of reproduction. 98(2):227-238
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