Gene
ephb3b
- ID
- ZDB-GENE-100811-1
- Name
- eph receptor B3b
- Symbol
- ephb3b Nomenclature History
- Previous Names
-
- epha3b
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within embryonic liver development. Is expressed in several structures, including basal plate midbrain region; margin; mesoderm; midbrain; and optic vesicle. Orthologous to human EPHB3 (EPH receptor B3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu779 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
1 - 5 of 13 Show all
Domain Details Per Protein
| Protein | Length | Ephrin receptor, transmembrane domain | Ephrin receptor tyrosine kinases | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PW29
|
564 | |||||||||||||
|
UniProtKB:A0A8M9PW34
|
479 | |||||||||||||
|
UniProtKB:A0A8M9PEN7
|
531 | |||||||||||||
|
UniProtKB:A0A8M9PSL5
|
560 | |||||||||||||
|
UniProtKB:A0A8M9PKC2
|
512 |
1 - 5 of 5
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365582 (1) | 4551 nt | ||
| Genomic | GenBank:LO016987 (1) | |||
| Polypeptide | UniProtKB:A0A8M9PW29 (1) | 564 aa |
- Trejo-Reveles, V., Owen, N., Ching Chan, B.H., Toms, M., Schoenebeck, J.J., Moosajee, M., Rainger, J., Genomics England Research Consortium (2023) Identification of Novel Coloboma Candidate Genes through Conserved Gene Expression Analyses across Four Vertebrate Species. Biomolecules. 13(2):
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Thestrup, M.I., Caviglia, S., Cayuso, J., Heyne, R.L.S., Ahmad, R., Hofmeister, W., Satriano, L., Wilkinson, D.G., Andersen, J.B., Ober, E.A. (2019) A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation. Nature communications. 10:5220
- Cayuso, J., Dzementsei, A., Fischer, J.C., Karemore, G., Caviglia, S., Bartholdson, J., Wright, G.J., Ober, E.A. (2016) EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell. 39:316-328
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Mo, W., and Nicolson, T. (2011) Both pre- and postsynaptic activity of nsf prevents degeneration of hair-cell synapses. PLoS One. 6(11):e27146
1 - 7 of 7
Show