Gene
kcnh2b
- ID
- ZDB-GENE-100629-2
- Name
- potassium voltage-gated channel, subfamily H (eag-related), member 2b
- Symbol
- kcnh2b Nomenclature History
- Previous Names
-
- kcnh2l
- zerg-24 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2).
- Genome Resources
-
- Alliance (1)
- Gene:100463518 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Leong et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| long QT syndrome 2 | Alliance | Long QT syndrome 2 | 613688 |
| short QT syndrome | Alliance | Short QT syndrome 1 | 609620 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | PAS domain | PAS domain superfamily | Potassium channel, voltage-dependent, ERG | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YY94
|
1177 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353973 (1) | 9585 nt | ||
| Genomic | GenBank:CABZ01057411 (1) | 39120 nt | ||
| Polypeptide | UniProtKB:A0A8M6YY94 (1) | 1177 aa |
- Comparative Orthology
- Alliance
- Pradhan, A., Ivarsson, P., Ragnvaldsson, D., Berg, H., Jass, J., Olsson, P.E. (2017) Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. The Science of the total environment. 584-585:1138-1146
- Leong, I.U., Skinner, J.R., Shelling, A.N., and Love, D.R. (2010) Identification and expression analysis of kcnh2 genes in the zebrafish. Biochemical and Biophysical Research Communications. 396(4):817-824
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