Gene
ptprnb
- ID
- ZDB-GENE-100505-1
- Name
- protein tyrosine phosphatase receptor type Nb
- Symbol
- ptprnb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and protein dephosphorylation. Predicted to localize to integral component of membrane and secretory granule. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from van Eekelen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR021613 | Protein-tyrosine phosphatase receptor IA-2 ectodomain |
| Domain | IPR029403 | RESP18 domain |
| Family | IPR033522 | Receptor-type tyrosine-protein phosphatase-like N/N2 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR038112 | Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase receptor IA-2 ectodomain | Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily | Receptor-type tyrosine-protein phosphatase-like N/N2 | RESP18 domain | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WH84
|
916 | |||||||||
|
UniProtKB:A0A8M9P942
|
945 | |||||||||
|
UniProtKB:A0A8M2BD60
|
945 | |||||||||
|
UniProtKB:A0A8M9PK91
|
916 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptprnb-201
(1)
|
Ensembl | 2,604 nt | ||
| mRNA |
ptprnb-202
(1)
|
Ensembl | 3,439 nt |
Interactions and Pathways
No data available
Plasmids
No data available