Gene
peak1
- ID
- ZDB-GENE-100422-1
- Name
- pseudopodium-enriched atypical kinase 1
- Symbol
- peak1 Nomenclature History
- Previous Names
-
- gb:eh551459 (1)
- si:dkey-7n16.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Acts upstream of or within angiogenesis and regulation of blood vessel endothelial cell migration. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8851 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24602 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32513 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44230 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf2170 | Allele with one deletion | Unknown | Frameshift | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mitochondrial Quality Control and Scaffold Kinases | Protein kinase domain | Protein kinase-like domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:X1WGC5
|
1725 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7N16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921567 (1) | 5866 nt | ||
| Genomic | GenBank:BX005076 (1) | 206504 nt | ||
| Polypeptide | UniProtKB:X1WGC5 (1) | 1725 aa |
- Wang, H., Lapek, J., Fujimura, K., Strnadel, J., Liu, B., Gonzalez, D.J., Zhang, W., Watson, F., Yu, V., Liu, C., Melo, C.M., Miller, Y.I., Elliott, K.C., Cheresh, D.A., Klemke, R.L. (2018) Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell discovery. 4:26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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