Gene
map3k8
- ID
- ZDB-GENE-100316-8
- Name
- mitogen-activated protein kinase kinase kinase 8
- Symbol
- map3k8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Lai et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13098 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Lung cancer, somatic | 211980 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase kinase kinase | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T7L4
|
472 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k8-201
(1)
|
Ensembl | 1,724 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-110M20 | ||
| Contained in | BAC | DKEY-181N13 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480321 (1) | 3542 nt | ||
| Genomic | GenBank:BX470141 (1) | 84274 nt | ||
| Polypeptide | UniProtKB:A0A8N7T7L4 (1) | 472 aa |
- Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
- Liyanage, T.D., Nikapitiya, C., Lee, J., De Zoysa, M. (2020) Molecular insight into regulation of miRNA in the spleen of zebrafish (Danio rerio) upon pathogenic Streptococcus parauberis infection. Fish & shellfish immunology. 106:898-909
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 3 of 3
Show