Gene

nlgn4xa

ID

ZDB-GENE-100309-2

Name

neuroligin 4 X-linked a

Symbol

nlgn4xa Nomenclature History

Previous Names

nlgn4a
nlgn4b (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Is expressed in several structures, including brain; eye; gonad; spinal cord interneuron; and swim bladder. Orthologous to several human genes including NLGN4X (neuroligin 4 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlgn4xa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, X-linked	300495
		{Autism susceptibility, X-linked 2}	300495

Associated With nlgn4xa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019819	Carboxylesterase type B, conserved site
Domain	IPR002018	Carboxylesterase, type B
Family	IPR000460	Neuroligin
Family	IPR051093	Neuroligin and Bile salt-activated lipase
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold