Gene

card11

ID

ZDB-GENE-100219-1

Name

caspase recruitment domain family, member 11

Symbol

card11 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have CARD domain binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and regulation of apoptotic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma and primary immunodeficiency disease. Is expressed in gill; intestine; kidney; spleen; and unfertilized egg. Orthologous to human CARD11 (caspase recruitment domain family member 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chang et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With card11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 11A	Alliance	Immunodeficiency 11A	615206
immunodeficiency 11B	Alliance	Immunodeficiency 11B with atopic dermatitis	617638
		B-cell expansion with NFKB and T-cell anergy	616452

Associated With card11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR001478	PDZ domain
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	CARD domain	Death-like domain superfamily	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M6YZ97 InterPro	1122
UniProtKB:A0A8M3B168 InterPro	1125

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	card11-201 (1) Ensembl	Ensembl	970 nt	Select Tool ZFIN BLAST
mRNA	card11-202 (1) Ensembl	Ensembl	4,308 nt	Select Tool
mRNA	card11-203 (1) Ensembl	Ensembl	351 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations