Gene
cyld2
- ID
- ZDB-GENE-100208-1
- Name
- cylindromatosis (turban tumor syndrome) 2
- Symbol
- cyld2 Nomenclature History
- Previous Names
-
- cyldb (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Predicted to be located in microtubule organizing center and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome and amyotrophic lateral sclerosis. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
- Genome Resources
- Note
-
03-Apr-2024 Examination of current data suggests this gene existed prior to the divergence of ray- and lobe-finned fishes; therefore, should not have a/b nomenclature
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000938 | CAP Gly-rich domain |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR036859 | CAP Gly-rich domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|
|
UniProtKB:E7F048
|
694 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance