Gene

lingo4b

ID

ZDB-GENE-091214-3

Name

leucine rich repeat and Ig domain containing 4b

Symbol

lingo4b Nomenclature History

Previous Names

zgc:198379

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to localize to extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in glaucoma. Is expressed in Purkinje cell; cerebellum; granule cell; hindbrain; and optic tectum. Orthologous to several human genes including LINGO1 (leucine rich repeat and Ig domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Takeuchi et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lingo4b Human Ortholog

No data available

Associated With lingo4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR050467	Leucine-rich repeat and fibronectin type-III domain-containing
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype
Repeat	IPR026906	BspA-type LRR region