Gene

vav2

ID

ZDB-GENE-091204-420

Name

vav 2 guanine nucleotide exchange factor

Symbol

vav2 Nomenclature History

Previous Names

si:dkeyp-116h7.3
wan

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in intracellular signal transduction. Predicted to localize to integral component of membrane. Is expressed in heart. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vav2 Human Ortholog

No data available

Associated With vav2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000980	SH2 domain
Domain	IPR001452	SH3 domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR022613	Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain
Domain	IPR035732	VAV2 protein, second SH3 domain
Domain	IPR035880	VAV2, SH2 domain
Domain	IPR037832	Vav, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain	Calponin homology domain	CH domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily	VAV2 protein, second SH3 domain	VAV2, SH2 domain	Vav, PH domain
UniProtKB:A0A8M9PR05 InterPro	890
UniProtKB:A0A8M3ALG5 InterPro	879
UniProtKB:A0A8M3AM66 InterPro	870
UniProtKB:A0A8M9P3P6 InterPro	886
UniProtKB:A0A8M9PPX7 InterPro	819
UniProtKB:A0A8M9PUI9 InterPro	891
UniProtKB:A0A8M6YV87 InterPro	880
UniProtKB:A0A8M3ATW1 InterPro	841
UniProtKB:A0A286Y8W8 InterPro	875
UniProtKB:A0A8M9PIU4 InterPro	862
UniProtKB:A0A8M3AWV3 InterPro	869

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	vav2-201 (1) Ensembl	Ensembl		3,826 nt	Select Tool
mRNA	vav2-202 (1) Ensembl	Ensembl		6,219 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations