Gene
dnah5l
- ID
- ZDB-GENE-091204-287
- Name
- dynein, axonemal, heavy chain 5 like
- Symbol
- dnah5l Nomenclature History
- Previous Names
-
- dnah8 (1)
- fj04c06
- si:dkeyp-87a6.1
- wu:fj04c06
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of outer dynein arm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9089 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11639 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12494 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13336 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16014 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24530 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30123 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32492 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | Dynein heavy chain, tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RI45
|
4667 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnah5l-201
(1)
|
Ensembl | 8,058 nt | ||
| mRNA |
dnah5l-204
(1)
|
Ensembl | 13,622 nt | ||
| ncRNA |
si:dkeyp-87a6.1-002
(1)
|
Ensembl | 286 nt | ||
| ncRNA |
si:dkeyp-87a6.1-003
(1)
|
Ensembl | 592 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-36G22 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-87A6 | ZFIN Curated Data | |
| Encodes | EST | fj04c06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002666688 (1) | 14099 nt | ||
| Genomic | GenBank:CU019563 (1) | 194521 nt | ||
| Polypeptide | UniProtKB:A0A8M1RI45 (1) | 4667 aa |
- Comparative Orthology
- Alliance
No data available
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7
- Li, Y., Yagi, H., Onuoha, E.O., Damerla, R.R., Francis, R., Furutani, Y., Tariq, M., King, S.M., Hendricks, G., Cui, C., Saydmohammed, M., Lee, D.M., Zahid, M., Sami, I., Leatherbury, L., Pazour, G.J., Ware, S.M., Nakanishi, T., Goldmuntz, E., Tsang, M., Lo, C.W. (2016) DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genetics. 12:e1005821
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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