Gene
panx3
- ID
- ZDB-GENE-091204-114
- Name
- pannexin 3
- Symbol
- panx3 Nomenclature History
- Previous Names
-
- si:dkey-263o8.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable channel activity. Acts upstream of or within cranial skeletal system development and ossification. Predicted to be located in gap junction and membrane. Is expressed in several structures, including dermal bone; eye; heart; liver; and pleuroperitoneal region. Orthologous to human PANX3 (pannexin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Oh et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Innexin | Pannexin |
|---|---|---|---|
|
UniProtKB:E7F7V4
|
444 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-263O8 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001919826 (1) | |||
| Genomic | GenBank:CR925737 (1) | 176029 nt | ||
| Polypeptide | UniProtKB:E7F7V4 (1) | 444 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Mouse | Panx3 | 9 | Amino acid sequence comparison (1) |
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Safarian, N., Houshangi-Tabrizi, S., Zoidl, C., Zoidl, G.R. (2021) Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. International Journal of Molecular Sciences. 22(21):
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Oh, S.K., Shin, J.O., Baek, J.I., Lee, J., Bae, J.W., Ankamerddy, H., Kim, M.J., Huh, T.L., Ryoo, Z.Y., Kim, U.K., Bok, J., Lee, K.Y. (2015) Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4473-84
- Kurtenbach, S., Prochnow, N., Kurtenbach, S., Klooster, J., Zoidl, C., Dermietzel, R., Kamermans, M., and Zoidl, G. (2013) Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One. 8(10):e77722
- Bond, S.R., Wang, N., Leybaert, L., and Naus, C.C. (2012) Pannexin 1 Ohnologs in the Teleost Lineage. The Journal of membrane biology. 245(8):483-493
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