Gene
odf2a
- ID
- ZDB-GENE-091117-46
- Name
- outer dense fiber of sperm tails 2a
- Symbol
- odf2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to be involved in regulation of cilium assembly. Predicted to be located in cytoplasm and microtubule organizing center. Predicted to be active in centrosome. Used to study microcephaly. Orthologous to human ODF2 (outer dense fiber of sperm tails 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12576 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12668 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16482 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39320 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-odf2a | N/A | (2) |
| MO2-odf2a | N/A | Novorol et al., 2013 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microcephaly | WT + MO2-odf2a | standard conditions | Novorol et al., 2013 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026099 | Outer dense fibre protein 2-related |
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Domain Details Per Protein
| Protein | Length | Outer dense fibre protein 2-related |
|---|---|---|
|
UniProtKB:E7F186
|
831 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-228B2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001332528 (1) | 4341 nt | ||
| Genomic | GenBank:CR792457 (1) | 163282 nt | ||
| Polypeptide | UniProtKB:E7F186 (1) | 831 aa |
- Aljiboury, A., Mujcic, A., Curtis, E., Cammerino, T., Magny, D., Lan, Y., Bates, M., Freshour, J., Ahmed-Braimeh, Y.H., Hehnly, H. (2022) Pericentriolar matrix (PCM) integrity relies on cenexin and Polo-Like Kinase (PLK)1. Molecular biology of the cell. 33(9):br14
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Novorol, C., Burkhardt, J., Wood, K.J., Iqbal, A., Roque, C., Coutts, N., Almeida, A.D., He, J., Wilkinson, C.J., and Harris, W.A. (2013) Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression. Open Biology. 3(10):130065
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