Gene

tead1b

ID

ZDB-GENE-091013-5

Name

TEA domain family member 1b

Symbol

tead1b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic organ development; hippo signaling; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ha et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tead1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Sveinsson chorioretinal atrophy	Alliance	Sveinsson chorioretinal atrophy	108985

Associated With tead1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000818	TEA/ATTS domain
Domain	IPR041086	YAP binding domain
Family	IPR016361	Transcriptional enhancer factor, metazoa
Family	IPR050937	TEC1/TEAD Transcription Factor
Homologous_superfamily	IPR038096	TEA/ATTS domain superfamily

Domain Details Per Protein

Protein	Length	TEA/ATTS domain	TEA/ATTS domain superfamily	TEC1/TEAD Transcription Factor	Transcriptional enhancer factor, metazoa	YAP binding domain
UniProtKB:A0A8M3AUN1 InterPro	414
UniProtKB:A0A8M3AUR1 InterPro	410
UniProtKB:A0A8M9PQ99 InterPro	363
UniProtKB:A0A8M9PS38 InterPro	401
UniProtKB:A0A8M3B1M0 InterPro	412
UniProtKB:A0A8M3B4I0 InterPro	433
UniProtKB:A0A8M9Q920 InterPro	393
UniProtKB:A0A8M3B4I3 InterPro	412
UniProtKB:A0A8M9QI50 InterPro	389
UniProtKB:A0A8M3BBE2 InterPro	429
UniProtKB:A0A8M9QD63 InterPro	384
UniProtKB:A0A8M3BBE7 InterPro	408

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tead1b-201 (1) Ensembl	Ensembl	1,173 nt	Select Tool ZFIN BLAST
mRNA	tead1b-202 (1) Ensembl	Ensembl	9,066 nt	Select Tool ZFIN BLAST
mRNA	tead1b-203 (1) Ensembl	Ensembl	1,233 nt	Select Tool ZFIN BLAST
mRNA	tead1b-204 (1) Ensembl	Ensembl	1,158 nt	Select Tool ZFIN BLAST
mRNA	tead1b-205 (1) Ensembl	Ensembl	1,095 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations