Gene
tead1b
- ID
- ZDB-GENE-091013-5
- Name
- TEA domain family member 1b
- Symbol
- tead1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic organ development; hippo signaling; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ha et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026244Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa41070 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sveinsson chorioretinal atrophy | Alliance | Sveinsson chorioretinal atrophy | 108985 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TEA/ATTS domain | TEA/ATTS domain superfamily | TEC1/TEAD Transcription Factor | Transcriptional enhancer factor, metazoa | YAP binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AUN1
|
414 | |||||
|
UniProtKB:A0A8M3AUR1
|
410 | |||||
|
UniProtKB:A0A8M9PQ99
|
363 | |||||
|
UniProtKB:A0A8M9PS38
|
401 | |||||
|
UniProtKB:A0A8M3B1M0
|
412 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tead1b-201
(1)
|
Ensembl | 1,173 nt | ||
| mRNA |
tead1b-202
(1)
|
Ensembl | 9,066 nt | ||
| mRNA |
tead1b-203
(1)
|
Ensembl | 1,233 nt | ||
| mRNA |
tead1b-204
(1)
|
Ensembl | 1,158 nt | ||
| mRNA |
tead1b-205
(1)
|
Ensembl | 1,095 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-288C23 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001435835 (1) | 9537 nt | ||
| Genomic | GenBank:CT573494 (1) | 132080 nt | ||
| Polypeptide | UniProtKB:A0A8M3B4I0 (1) | 433 aa |
- Ha, T.T., Burgess, R., Newman, M., Moey, C., Mandelstam, S.A., Gardner, A.E., Ivancevic, A.M., Pham, D., Kumar, R., Smith, N., Patel, C., Malone, S., Ryan, M.M., Calvert, S., van Eyk, C.L., Lardelli, M., Berkovic, S.F., Leventer, R.J., Richards, L.J., Scheffer, I.E., Gecz, J., Corbett, M.A. (2023) Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes. 14(8):
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, H. (2009) Comparative genomic analysis of teleost fish bmal genes. Genetica. 136(1):149-161
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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