Gene

kdm6ba

ID

ZDB-GENE-091005-1

Name

lysine (K)-specific demethylase 6B, a

Symbol

kdm6ba Nomenclature History

Previous Names

jmjd3b (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have histone demethylase activity (H3-K27 specific) and metal ion binding activity. Involved in heart development and heart trabecula morphogenesis. Predicted to localize to nucleus. Is expressed in brain; heart; and otic vesicle. Orthologous to human KDM6B (lysine demethylase 6B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Akerberg et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm6ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Stolerman neurodevelopmental syndrome	Alliance	Stolerman neurodevelopmental syndrome	618505

Associated With kdm6ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003347	JmjC domain
Domain	IPR048560	Lysine-specific demethylase 6A/B-like, GATA-like
Domain	IPR048562	Lysine-specific demethylase 6A/B-like, C-terminal helical domain
Family	IPR051630	Transcriptional Corepressor and Histone Demethylase
Homologous_superfamily	IPR046941	Lysine-specific demethylase 6, GATA-like domain superfamily

Domain Details Per Protein

Protein	Length	JmjC domain	Lysine-specific demethylase 6A/B-like, C-terminal helical domain	Lysine-specific demethylase 6A/B-like, GATA-like	Lysine-specific demethylase 6, GATA-like domain superfamily	Transcriptional Corepressor and Histone Demethylase
UniProtKB:A0A8M3AU53 InterPro	1996

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kdm6ba-201 (1) Ensembl	Ensembl	1,578 nt	Select Tool ZFIN BLAST
mRNA	kdm6ba-203 (1) Ensembl	Ensembl	8,578 nt	Select Tool
ncRNA	kdm6ba-002 (1) Ensembl	Ensembl	855 nt	Select Tool
ncRNA	kdm6ba-003 (1) Ensembl	Ensembl	706 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations