Gene
fancm
- ID
- ZDB-GENE-090929-1
- Name
- FA complementation group M
- Symbol
- fancm Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have 3'-5' DNA helicase activity; four-way junction DNA binding activity; and four-way junction helicase activity. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing; interstrand cross-link repair; and replication fork reversal. Human ortholog(s) of this gene implicated in male infertility and premature ovarian failure. Is expressed in central nervous system; eye; and lens. Orthologous to human FANCM (FA complementation group M).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 15 | Alliance | Premature ovarian failure 15 | 618096 |
| spermatogenic failure 28 | Alliance | Spermatogenic failure 28 | 618086 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR006166 | ERCC4 domain |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR031879 | Fanconi anemia group M protein, MHF binding domain |
| Domain | IPR039686 | FANCM/Mph1-like, insert domain |
| Domain | IPR044749 | FANCM, DEAH-box helicase domain |
| Domain | IPR047418 | Fanconi anemia group M protein, XPF-like nuclease domain |
| Homologous_superfamily | IPR010994 | RuvA domain 2-like |
| Homologous_superfamily | IPR011335 | Restriction endonuclease type II-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | DEAD/DEAH box helicase domain | ERCC4 domain | FANCM, DEAH-box helicase domain | FANCM/Mph1-like, insert domain | Fanconi anemia group M protein, MHF binding domain | Fanconi anemia group M protein, XPF-like nuclease domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Restriction endonuclease type II-like | RuvA domain 2-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8QLH8
|
1761 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available