Gene

grm1b

ID

ZDB-GENE-090821-3

Name

glutamate receptor, metabotropic 1b

Symbol

grm1b Nomenclature History

Previous Names

grm1a
si:ch211-278p9.5
zmp:0000000607

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grm1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 13	Alliance	Spinocerebellar ataxia, autosomal recessive 13	614831
spinocerebellar ataxia 44	Alliance	Spinocerebellar ataxia 44	617691

Associated With grm1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017979	GPCR, family 3, conserved site
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR011500	GPCR, family 3, nine cysteines domain
Domain	IPR017978	GPCR family 3, C-terminal
Domain	IPR019588	Metabotropic glutamate receptor, Homer-binding domain
Family	IPR000162	GPCR, family 3, metabotropic glutamate receptor
Family	IPR000337	GPCR, family 3
Family	IPR001256	GPCR, family 3, metabotropic glutamate receptor 1
Family	IPR050726	Metabotropic Glutamate Receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR038550	GPCR, family 3, nine cysteines domain superfamily