Gene
tcf4
- ID
- ZDB-GENE-090814-1
- Name
- transcription factor 4
- Symbol
- tcf4 Nomenclature History
- Previous Names
-
- tcf4l
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have protein dimerization activity. Involved in brain development and lens development in camera-type eye. Used to study Pitt-Hopkins syndrome. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Is expressed in several structures, including brain; digestive system; notochord; pectoral fin bud; and retina. Orthologous to human TCF4 (transcription factor 4).
- Genome Resources
-
- Alliance (1)
- Gene:100526651 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 3 | 613267 |
| Pitt-Hopkins syndrome | Alliance | Pitt-Hopkins syndrome | 610954 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Pitt-Hopkins syndrome | AB/TU + MO1-tcf4 + MO2-tcf4 | standard conditions | Brockschmidt et al., 2011 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR051098 | Neuronal Differentiation E-box Binding Transcription Factors |
Domain Details Per Protein
| Protein | Length | Neuronal Differentiation E-box Binding Transcription Factors |
|---|---|---|
|
UniProtKB:A0A8M9P3H6
|
496 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance