Gene
slc1a3b
- ID
- ZDB-GENE-090708-3
- Name
- solute carrier family 1 member 3b
- Symbol
- slc1a3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in D-aspartate import across plasma membrane; L-aspartate import across plasma membrane; and L-glutamate import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa34953 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| episodic ataxia type 6 | Alliance | Episodic ataxia, type 6 | 612656 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dicarboxylate/Amino Acid:Cation Symporter | Sodium:dicarboxylate symporter | Sodium:dicarboxylate symporter, conserved site | Sodium:dicarboxylate symporter superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q657
|
280 | ||||
|
UniProtKB:D7RVS0
|
537 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc1a3b-201
(1)
|
Ensembl | 1,630 nt | ||
| mRNA |
slc1a3b-202
(1)
|
Ensembl | 1,724 nt |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21N12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001190303 (1) | 1630 nt | ||
| Genomic | GenBank:AL929053 (1) | 142345 nt | ||
| Polypeptide | UniProtKB:D7RVS0 (1) | 537 aa |
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Zhu, J., Zhang, Y., Xu, Y., Wang, L., Wu, Q., Zhang, Z., Li, L. (2022) Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae. Marine Environmental Research. 176:105615
- Hotz, A.L., Jamali, A., Rieser, N.N., Niklaus, S., Aydin, E., Myren-Svelstad, S., Lalla, L., Jurisch-Yaksi, N., Yaksi, E., Neuhauss, S.C.F. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. 70(1):196-214
- Umans, R.A., Pollock, C., Mills, W.A., Clark, K.C., Pan, Y.A., Sontheimer, H. (2021) Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Frontiers in cell and developmental biology. 9:654338
- Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306
- Wang, J., Jia, B., Li, Y., Ren, B., Liang, H., Yan, D., Xie, H., Zhang, X., Liang, H. (2020) Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio). Journal of hazardous materials. 397:122724
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Pasquier, J., Braasch, I., Batzel, P., Cabau, C., Montfort, J., Nguyen, T., Jouanno, E., Berthelot, C., Klopp, C., Journot, L., Postlethwait, J.H., Guiguen, Y., Bobe, J. (2017) Evolution of gene expression after whole-genome duplication: New insights from the spotted gar genome. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):709-721
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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