Gene
f8
- ID
- ZDB-GENE-090629-2
- Name
- coagulation factor VIII, procoagulant component
- Symbol
- f8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable copper ion binding activity and oxidoreductase activity. Acts upstream of or within blood coagulation; glial cell development; and retina development in camera-type eye. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor VIII deficiency | Alliance | Hemophilia A | 306700 |
| Thrombophilia 13, X-linked, due to factor VIII defect | 301071 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| factor VIII deficiency | f8sa19072/sa19072 | standard conditions | Dhinoja et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR011706 | Multicopper oxidase, C-terminal |
| Family | IPR024715 | Coagulation factor 5/8-like |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008972 | Cupredoxin |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Coagulation factor 5/8-like | Cupredoxin | Galactose-binding-like domain superfamily | Multicopper oxidase, C-terminal | Multicopper oxidases, conserved site | Neuropilin/Multicopper Oxidase/Coagulation Factor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3BEX0
|
1668 |
Interactions and Pathways
No data available
Plasmids
No data available