Gene

cacna1g

ID

ZDB-GENE-090514-2

Name

calcium channel, voltage-dependent, T type, alpha 1G subunit

Symbol

cacna1g Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in several processes, including calcium ion import; neuronal action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to localize to neuron projection and voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42. Is expressed in atrium and cardiac ventricle. Orthologous to human CACNA1G (calcium voltage-gated channel subunit alpha1 G).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna1g Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia type 42	Alliance	Spinocerebellar ataxia 42	616795
		Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	618087

Associated With cacna1g Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Family	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
Family	IPR005445	Voltage-dependent calcium channel, T-type, alpha-1 subunit
Family	IPR043203	Voltage-gated cation channel calcium and sodium
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Voltage-dependent calcium channel, alpha-1 subunit	Voltage-dependent calcium channel, T-type, alpha-1 subunit	Voltage-dependent channel domain superfamily	Voltage-gated cation channel calcium and sodium
UniProtKB:A0A8M9QER5 InterPro	2414
UniProtKB:A0A8M9QJ76 InterPro	2462
UniProtKB:A0A8M6Z8Y9 InterPro	2456
UniProtKB:A0A8M6Z3L0 InterPro	2469
UniProtKB:A0A8M6Z219 InterPro	2447
UniProtKB:A0A8M9PX46 InterPro	2462
UniProtKB:A0A8M9QER1 InterPro	2503
UniProtKB:A0A8M9Q929 InterPro	2440

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cacna1g-201 (1) Ensembl	Ensembl		6,720 nt	Select Tool ZFIN BLAST
mRNA	cacna1g-202 (1) Ensembl	Ensembl		5,635 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations