Gene
tuba1a
- ID
- ZDB-GENE-090507-4
- Name
- tubulin, alpha 1a
- Symbol
- tuba1a Nomenclature History
- Previous Names
-
- tuba1l2
- wu:fb37a10
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity. Involved in negative regulation of apoptotic process and optic nerve formation. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in lissencephaly; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85639 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Veldman et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
lissencephaly 3 | Alliance | Lissencephaly 3 | 611603 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017975 | Tubulin, conserved site |
Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
Family | IPR000217 | Tubulin |
Family | IPR002452 | Alpha tubulin |
Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
Protein | Length | Alpha tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6NWK7
|
451 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
tuba1a-201
(1)
|
Havana | 1537 nt |
Interactions and Pathways
No data available
Plasmids
No data available