Gene
pcsk1nl
- ID
- ZDB-GENE-090427-2
- Name
- proprotein convertase subtilisin/kexin type 1 inhibitor, like
- Symbol
- pcsk1nl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of endopeptidase activity. Is expressed in adenohypophyseal placode; nervous system; and pancreas.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12969 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27131 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41118 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010832 | ProSAAS |
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Domain Details Per Protein
| Protein | Length | ProSAAS |
|---|---|---|
|
UniProtKB:F1QCH5
|
333 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcsk1nl-201
(1)
|
Ensembl | 3,759 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-150E8 | ||
| Encodes | EST | fj32g06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166129 (1) | 3761 nt | ||
| Genomic | GenBank:BX469901 (1) | 180553 nt | ||
| Polypeptide | UniProtKB:F1QCH5 (1) | 333 aa |
No data available
- Teixeira, C.M.M., Correa, C.N., Iwai, L.K., Ferro, E.S., Castro, L.M. (2019) Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Zebrafish. 16(3):240-251
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Van Camp, K.A., Baggerman, G., Blust, R., Husson, S.J. (2017) Peptidomics of the zebrafish Danio rerio: In search for neuropeptides. Journal of proteomics. 150:290-296
- Lopes, M.W., Sapio, M.R., Leal, R.B., Fricker, L.D. (2016) Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. PLoS One. 11:e0152905
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kudo, H., Liu, J., Jansen, E.J., Ozawa, A., Panula, P., Martens, G.J., and Lindberg, I. (2009) Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. Endocrinology. 150(3):1393-1399
- Toro, S., Wegner, J., Muller, M., Westerfield, M., and Varga, Z.M. (2009) Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Gene expression patterns : GEP. 9(4):200-208
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