Gene
chrm2b
- ID
- ZDB-GENE-090410-3
- Name
- cholinergic receptor, muscarinic 2b
- Symbol
- chrm2b Nomenclature History
- Previous Names
-
- si:dkeyp-8b11.3
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of smooth muscle contraction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Muscarinic acetylcholine receptor family |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q5D6
|
476 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrm2b-202
(1)
|
Ensembl | 1,401 nt | ||
| mRNA |
chrm2b-203
(1)
|
Ensembl | 6,272 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-8B11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068219405 (1) | 1479 nt | ||
| Genomic | GenBank:BX004889 (1) | 253422 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q5D6 (1) | 476 aa |
- Siregar, P., Audira, G., Feng, L.Y., Lee, J.H., Santoso, F., Yu, W.H., Lai, Y.H., Li, J.H., Lin, Y.T., Chen, J.R., Hsiao, C.D. (2021) Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. toxins. 13(4):
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2018) Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. eNeuro. 5(5):
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Nuckels, R.J., Forstner, M.R., Capalbo-Pitts, E.L., and García, D.M. (2011) Developmental expression of muscarinic receptors in the eyes of zebrafish. Brain research. 1405:85-94
- Seo, J.S., Kim, M.S., Park, E.M., Ahn, S.J., Kim, N.Y., Jung, S.H., Kim, J.W., Lee, H.H., and Chung, J.K. (2009) Cloning and characterization of muscarinic receptor genes from the nile tilapia (Oreochromis niloticus). Molecules and cells. 27(3):383-390
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