Gene
vwc2
- ID
- ZDB-GENE-090313-315
- Name
- von Willebrand factor C domain containing 2
- Symbol
- vwc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within forebrain development. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. Is expressed in brain; olfactory system; and spinal cord. Orthologous to human VWC2 (von Willebrand factor C domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Miyake et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa30970 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | von Willebrand factor C domain-containing protein 2-like | VWFC domain |
|---|---|---|---|
|
UniProtKB:B0I1T8
|
309 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4J1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114628 (1) | 930 nt | ||
| Genomic | GenBank:CR762498 (2) | 76364 nt | ||
| Polypeptide | UniProtKB:B0I1T8 (1) | 309 aa |
No data available
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Dong, Z., Li, Y., Chen, X., Lai, X., Liu, M. (2020) A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 251:110522
- Miyake, A., Mekata, Y., Fujibayashi, H., Nakanishi, K., Konishi, M., Itoh, N. (2017) Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. PLoS One. 12:e0176036
- Miwa, H., Miyake, A., Kouta, Y., Shimada, A., Yamashita, Y., Nakayama, Y., Yamauchi, H., Konishi, M., and Itoh, N. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS letters. 583(22):3643-3648
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