Gene

wdr19

ID

ZDB-GENE-090313-277

Name

WD repeat domain 19

Symbol

wdr19 Nomenclature History

Previous Names

si:dkey-251e24.6

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Involved in cilium assembly. Predicted to localize to cilium and intraciliary transport particle A. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; Sensenbrenner syndrome; asphyxiating thoracic dystrophy 5; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ryan et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr19 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asphyxiating thoracic dystrophy 5	Alliance	Short-rib thoracic dysplasia 5 with or without polydactyly	614376
cranioectodermal dysplasia 4	Alliance	Cranioectodermal dysplasia 4	614378
nephronophthisis 13	Alliance	Nephronophthisis 13	614377
spermatogenic failure 72	Alliance	?Spermatogenic failure 72	619867
		Senior-Loken syndrome 8	616307

Associated With wdr19 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain
Family	IPR040379	WD repeat-containing protein 19/dyf-2
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR039468	WDR19, WD40 repeat

Domain Details Per Protein

Protein	Length	Anaphase-promoting complex subunit 4-like, WD40 domain	Tetratricopeptide-like helical domain superfamily	WD40 repeat	WD40/YVTN repeat-like-containing domain superfamily	WDR19, WD40 repeat	WD repeat-containing protein 19/dyf-2
UniProtKB:A0A8M9PX63 InterPro	1345
UniProtKB:A0A8M9Q0I2 InterPro	1348
UniProtKB:A0A8M9QEB4 InterPro	1345

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wdr19-201 (1) Ensembl	Ensembl	4,352 nt	Select Tool
mRNA	wdr19-202 (1) Ensembl	Ensembl	724 nt	Select Tool
mRNA	wdr19-204 (1) Ensembl	Ensembl	4,119 nt	Select Tool ZFIN BLAST
mRNA	wdr19-205 (1) Ensembl	Ensembl	390 nt	Select Tool ZFIN BLAST
mRNA	wdr19-206 (1) Ensembl	Ensembl	324 nt	Select Tool ZFIN BLAST
mRNA	wdr19-207 (1) Ensembl	Ensembl	2,574 nt	Select Tool ZFIN BLAST
ncRNA	wdr19-003 (1) Ensembl	Ensembl	501 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations