Gene

rapgef3

ID

ZDB-GENE-090312-38

Name

Rap guanine nucleotide exchange factor (GEF) 3

Symbol

rapgef3 Nomenclature History

Previous Names

si:dkey-27m20.2

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in neuromast. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rapgef3 Human Ortholog

No data available

Associated With rapgef3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
Domain	IPR000591	DEP domain
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	DEP domain	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Ras guanine-nucleotide exchange factor, conserved site	Ras guanine nucleotide exchange factor domain superfamily	Ras guanine-nucleotide exchange factors catalytic domain	Ras-like guanine nucleotide exchange factor	Ras-like guanine nucleotide exchange factor, N-terminal	RmlC-like jelly roll fold	Ubiquitin-like domain superfamily	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:E7FDC9 InterPro	867
UniProtKB:A0A8M2B9K2 InterPro	885
UniProtKB:A0A8M3ANW0 InterPro	856
UniProtKB:A0A8M3B6B9 InterPro	861

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rapgef3-201 (1) Ensembl	Ensembl	3,091 nt	Select Tool ZFIN BLAST
mRNA	rapgef3-203 (1) Ensembl	Ensembl	2,475 nt	Select Tool ZFIN BLAST
ncRNA	rapgef3-002 (1) Ensembl	Ensembl	538 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations