Gene
ggt1l2.2
- ID
- ZDB-GENE-090312-37
- Name
- gamma-glutamyltransferase 1 like 2.2
- Symbol
- ggt1l2.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable glutathione hydrolase activity. Predicted to be involved in several processes, including glutathione catabolic process; peptide modification; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000101 | Gamma-glutamyltranspeptidase |
| Homologous_superfamily | IPR029055 | Nucleophile aminohydrolases, N-terminal |
| Homologous_superfamily | IPR043137 | Gamma-glutamyltranspeptidase, small subunit |
| Homologous_superfamily | IPR043138 | Gamma-glutamyltranspeptidase, large subunit, C-terminal domain |
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Domain Details Per Protein
| Protein | Length | Gamma-glutamyltranspeptidase | Gamma-glutamyltranspeptidase, large subunit, C-terminal domain | Gamma-glutamyltranspeptidase, small subunit | Nucleophile aminohydrolases, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:F8W3T7
|
566 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cu914631.1-201
(1)
|
Ensembl | 1,474 nt | ||
| mRNA |
ggt1l2.2-201
(1)
|
Ensembl | 1,823 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-59P9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-222H21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009295754 (1) | |||
| Genomic | GenBank:CR769768 (1) | 257616 nt | ||
| Polypeptide | UniProtKB:F8W3T7 (1) | 566 aa |
No data available
- Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
- Law, S.H., Redelings, B.D., and Kullman, S.W. (2012) Comparative genomics of duplicate gamma-glutamyl transferase genes in teleosts: medaka (Oryzias latipes), stickleback (Gasterosteus aculeatus), green spotted pufferfish (Tetraodon nigroviridis), fugu (Takifugu rubripes), and zebrafish (Danio rerio). Journal of experimental zoology. Part B, Molecular and developmental evolution. 318(1):35-49
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