Gene
rin2a
- ID
- ZDB-GENE-090312-194
- Name
- Ras and Rab interactor 2a
- Symbol
- rin2a Nomenclature History
- Previous Names
-
- rin2
- si:dkey-187a12.6
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within regulation of sprouting angiogenesis and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kempers et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Macrocephaly, alopecia, cutis laxa, and scoliosis | 613075 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000159 | Ras-associating domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR003123 | VPS9 domain |
| Family | IPR045046 | Vacuolar protein sorting-associated protein 9-like |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
| Homologous_superfamily | IPR037191 | VPS9 domain superfamily |
Domain Details Per Protein
| Protein | Length | Ras-associating domain | SH2 domain | SH2 domain superfamily | Ubiquitin-like domain superfamily | Vacuolar protein sorting-associated protein 9-like | VPS9 domain | VPS9 domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AZ86
|
839 | |||||||
|
UniProtKB:E7F662
|
938 |
Interactions and Pathways
No data available
Plasmids
No data available