Gene

kcnq5a

ID

ZDB-GENE-090312-185

Name

potassium voltage-gated channel, KQT-like subfamily, member 5a

Symbol

kcnq5a Nomenclature History

Previous Names

si:dkey-29l6.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in central nervous system; cerebellum; optic tectum; preoptic area; and telencephalon. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnq5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 46	Alliance	Intellectual developmental disorder, autosomal dominant 46	617601

Associated With kcnq5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR013821	Potassium channel, voltage dependent, KCNQ, C-terminal
Family	IPR003937	Potassium channel, voltage dependent, KCNQ
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Potassium channel, voltage dependent, KCNQ	Potassium channel, voltage dependent, KCNQ, C-terminal	Voltage-dependent channel domain superfamily
UniProtKB:A0A8M9QG06 InterPro	938
UniProtKB:A0A8M9PYN5 InterPro	1011
UniProtKB:A0A8M9QK86 InterPro	1030
UniProtKB:A0A8M9QAC3 InterPro	957

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kcnq5a-201 (1) Ensembl	Ensembl	3,353 nt	Select Tool ZFIN BLAST
mRNA	kcnq5a-202 (1) Ensembl	Ensembl	2,790 nt	Select Tool ZFIN BLAST
mRNA	kcnq5a-203 (1) Ensembl	Ensembl	518 nt	Select Tool ZFIN BLAST
mRNA	kcnq5a-204 (1) Ensembl	Ensembl	1,353 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations