Gene

megf6a

ID

ZDB-GENE-090312-12

Name

multiple EGF-like-domains 6a

Symbol

megf6a Nomenclature History

Previous Names

si:dkey-25b23.2 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Orthologous to human MEGF6 (multiple EGF like domains 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Teerlink et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With megf6a Human Ortholog

No data available

Associated With megf6a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR011489	EMI domain
Domain	IPR013111	EGF-like domain, extracellular
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR052108	Multiple EGF-like domains/Integrin beta-like
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-like domain, extracellular	EGF-type aspartate/asparagine hydroxylation site	EMI domain	Growth factor receptor cysteine-rich domain superfamily	Laminin-type EGF domain	Multiple EGF-like domains/Integrin beta-like	NOTCH1 EGF-like calcium-binding domain
UniProtKB:A0A8M9PWW0 InterPro	1513
UniProtKB:A0A8M6Z4L7 InterPro	1513
UniProtKB:A0A8M9Q7W7 InterPro	1456
UniProtKB:A0A8M3AYG1 InterPro	1456

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	megf6a-201 (1) Ensembl	Ensembl		4,272 nt	Select Tool ZFIN BLAST
mRNA	megf6a-202 (1) Ensembl	Ensembl		5,093 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations