Gene

cnnm2b

ID

ZDB-GENE-090311-26

Name

cyclin and CBS domain divalent metal cation transport mediator 2b

Symbol

cnnm2b Nomenclature History

Previous Names

cnnm2
si:ch211-176l1.6 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Involved in brain development and magnesium ion homeostasis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnnm2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
renal hypomagnesemia 6	Alliance	Hypomagnesemia 6, renal	613882
		Hypomagnesemia, seizures, and impaired intellectual development 1	616418

Associated With cnnm2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
schizophrenia	cnnm2b^a258/a258	standard conditions	Thyme et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000644	CBS domain
Domain	IPR002550	CNNM, transmembrane domain
Domain	IPR044751	Ion transporter-like, CBS domain
Family	IPR045095	Ancient conserved domain protein family
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily
Homologous_superfamily	IPR046342	CBS domain superfamily

Domain Details Per Protein

Protein	Length	Ancient conserved domain protein family	CBS domain	CBS domain superfamily	CNNM, transmembrane domain	Cyclic nucleotide-binding domain superfamily	Ion transporter-like, CBS domain
UniProtKB:A0A8M3AJ29 InterPro	830
UniProtKB:F1QIW8 InterPro	807

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cnnm2b-201 (1) Ensembl	Ensembl		4,352 nt	Select Tool
mRNA	cnnm2b-202 (1) Ensembl	Ensembl		2,351 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations