Gene

mapk8ip3

ID

ZDB-GENE-090303-6

Name

mitogen-activated protein kinase 8 interacting protein 3

Symbol

mapk8ip3 Nomenclature History

Previous Names

jip3 (1)
JNK-interacting protein 3 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have JUN kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in regulation of JNK cascade and retrograde axonal transport. Predicted to localize to cytoplasm. Is expressed in central nervous system; peripheral nervous system; and posterior lateral line ganglion. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Drerup et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk8ip3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without variable brain abnormalities	618443

Associated With mapk8ip3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032486	JNK-interacting protein, leucine zipper II
Domain	IPR034743	RH1 domain
Domain	IPR034744	RH2 domain
Family	IPR039911	JNK-interacting protein 3/4
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily