Gene
eif2ak4
- ID
- ZDB-GENE-090302-1
- Name
- eukaryotic translation initiation factor 2 alpha kinase 4
- Symbol
- eif2ak4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4).
- Genome Resources
-
- Alliance (1)
- Gene:100149925 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pulmonary venoocclusive disease 2 | Alliance | Pulmonary venoocclusive disease 2 | 234810 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR006575 | RWD domain |
| Domain | IPR024435 | Histidyl tRNA synthetase-related domain |
| Domain | IPR041715 | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain |
| Family | IPR016255 | eIF-2-alpha kinase Gcn2 |
| Family | IPR050339 | Cell Cycle and Stress Response Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Anticodon-binding domain superfamily | Cell Cycle and Stress Response Kinase | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | eIF-2-alpha kinase Gcn2 | Histidyl tRNA synthetase-related domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RWD domain | Serine/threonine-protein kinase, active site | Ubiquitin-conjugating enzyme/RWD-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YXD0
|
1624 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance