Gene

a2ml

ID

ZDB-GENE-090212-1

Name

alpha-2-macroglobulin-like

Symbol

a2ml Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have endopeptidase inhibitor activity. Involved in liver development. Predicted to localize to extracellular space. Is expressed in gut; liver; yolk; and yolk syncytial layer.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With a2ml Human Ortholog

No data available

Associated With a2ml Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019742	Alpha-2-macroglobulin, conserved site
Conserved_site	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain	IPR001599	Alpha-2-macroglobulin
Domain	IPR002890	Macroglobulin domain
Domain	IPR009048	Alpha-macroglobulin, receptor-binding
Domain	IPR011625	Alpha-2-macroglobulin, bait region domain
Domain	IPR011626	Alpha-macroglobulin-like, TED domain
Domain	IPR040839	Macroglobulin domain MG4
Domain	IPR041555	Macroglobulin domain MG3
Domain	IPR041813	Alpha-2-macroglobulin, TED domain
Family	IPR050473	Alpha-2-macroglobulin/Complement system
Homologous_superfamily	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily