Gene
crhr1
- ID
- ZDB-GENE-081231-1
- Name
- corticotropin releasing hormone receptor 1
- Symbol
- crhr1 Nomenclature History
- Previous Names
-
- crfr1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Is expressed in griseum centrale and hindbrain. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Faught et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR003051 | GPCR, family 2, corticotropin releasing factor receptor |
| Family | IPR003052 | GPCR, family 2, corticotropin releasing factor receptor, type 1 |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Length | GPCR, family 2, corticotropin releasing factor receptor | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WHD4
|
430 |
Interactions and Pathways
No data available
Plasmids