Gene

prf1.5

ID
ZDB-GENE-081105-3
Name
perforin 1.5
Symbol
prf1.5 Nomenclature History
Previous Names
  • prf8a (1)
  • si:ch211-103n10.4
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Predicted to be involved in cytolysis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Is expressed in gill; liver; muscle; and pleuroperitoneal region. Orthologous to human PRF1 (perforin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prf1.5 Human Ortholog
No data available
Associated With prf1.5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR000008 C2 domain
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Domain IPR037300 Perforin-1, C2 domain
Family IPR052784 Perforin-1 pore-forming
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Perforin-1, C2 domain Perforin-1 pore-forming
UniProtKB:A0A8N7UYU9 517
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prf1.5-201 (1) Ensembl 1,643 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations