Gene
doc2g
- ID
- ZDB-GENE-081104-451
- Name
- double C2-like domains, gamma
- Symbol
- doc2g Nomenclature History
- Previous Names
-
- doc2d
- si:dkeyp-110g5.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to be involved in exocytosis; regulation of calcium ion-dependent exocytosis; and spontaneous neurotransmitter secretion. Predicted to be located in membrane. Predicted to be active in synapse.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa41143 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Rabphilin/Doc2, first C2 domain | Rabphilin/Doc2/Noc2 | Synaptotagmin |
|---|---|---|---|---|---|---|
|
UniProtKB:B0V2S0
|
429 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-110G5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128554 (1) | 1667 nt | ||
| Genomic | GenBank:CT025854 (1) | 184858 nt | ||
| Polypeptide | UniProtKB:B0V2S0 (1) | 429 aa |
No data available
- Safian, D., Bogerd, J., Schulz, R.W. (2019) Regulation of spermatogonial development by Fsh: the complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. General and comparative endocrinology. 284:113244
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kumar, A., Bhandari, A., Sarde, S.J., Goswami, C. (2014) Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish. Biochemical and Biophysical Research Communications. 450(1):219-26
- Craxton, M. (2010) A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology. BMC Genomics. 11:37
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