Gene
lzts1
- ID
- ZDB-GENE-081104-431
- Name
- leucine zipper, putative tumor suppressor 1
- Symbol
- lzts1 Nomenclature History
- Previous Names
-
- si:dkey-63d15.13
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Predicted to be involved in regulation of dendrite morphogenesis and regulation of synaptic plasticity. Predicted to act upstream of or within mitotic cell cycle phase transition. Predicted to be active in dendritic spine. Is expressed in female organism. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| esophageal cancer | Alliance | Esophageal squamous cell carcinoma, somatic | 133239 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR045329 | Leucine zipper putative tumor suppressor |
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Domain Details Per Protein
| Protein | Length | Leucine zipper putative tumor suppressor |
|---|---|---|
|
UniProtKB:A0A8M9QA69
|
539 | |
|
UniProtKB:A0A8N7TFD8
|
712 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-63D15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009304165 (1) | |||
| Genomic | GenBank:BX005328 (1) | 272840 nt | ||
| Polypeptide | UniProtKB:A0A8N7TFD8 (1) | 712 aa |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aoki, M., Segawa, H., Naito, M., and Okamoto, H. (2014) Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochemical and Biophysical Research Communications. 445(2):357-362
- Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J.C., Yang, L., Baader, I., Reischl, M., Legradi, J., Mikut, R., Stemple, D., Ijcken, W.V., van der Sloot, A., Lenhard, B., Strähle, U., and Rastegar, S. (2013) Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Developmental Biology. 380(2):351-62
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