Gene
adgra2
- ID
- ZDB-GENE-081104-363
- Name
- adhesion G protein-coupled receptor A2
- Symbol
- adgra2 Nomenclature History
- Previous Names
-
- gpr124
- si:dkey-208c22.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within Wnt signaling pathway; blood vessel morphogenesis; and dorsal root ganglion development. Located in plasma membrane. Part of Wnt signalosome. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Harty et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 27 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s984 | Allele with one delins | Exon 7 | Premature Stop | TALEN | |
| s985 | Allele with one deletion | Exon 16 | Premature Stop | TALEN | |
| sa8749 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31669 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sj22 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ulb13 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ulb14 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| w192 | Allele with one point mutation | Donor Splice Site of Intron 4 | Exon Loss of Exon 4 | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Adhesion G protein-coupled receptor A | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0U2ULT4
|
1367 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgra2-201
(1)
|
Ensembl | 4,778 nt | ||
| mRNA |
adgra2-202
(1)
|
Ensembl | 2,917 nt | ||
| mRNA |
adgra2-203
(1)
|
Ensembl | 4,706 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-208C22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001318071 (1) | |||
| Genomic | GenBank:CR855861 (1) | 200837 nt | ||
| Polypeptide | UniProtKB:A0A0U2ULT4 (1) | 1367 aa |
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- America, M., Bostaille, N., Eubelen, M., Martin, M., Stainier, D.Y.R., Vanhollebeke, B. (2022) An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell Reports. 39:110902
- Bump, R.G., Goo, C.E.A., Horton, E.C., Rasmussen, J.P. (2022) Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis. Development (Cambridge, England). 149(3):
- Fetsko, A.R., Sebo, D.J., Taylor, M.R. (2022) Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis. Developmental Biology. 494:46-59
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Xu, Y., Luo, L., Chen, J. (2022) Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling. Ecotoxicology and environmental safety. 238:113620
- Jensen, L.D., Hot, B., Ramsköld, D., Germano, R.F.V., Yokota, C., Giatrellis, S., Lauschke, V.M., Hubmacher, D., Li, M.X., Hupe, M., Arnold, T.D., Sandberg, R., Frisén, J., Trusohamn, M., Martowicz, A., Wisniewska-Kruk, J., Nyqvist, D., Adams, R.H., Apte, S.S., Vanhollebeke, B., Stenman, J.M., Kele, J. (2019) Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1432-1447
- Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
- Hübner, K., Cabochette, P., Diéguez-Hurtado, R., Wiesner, C., Wakayama, Y., Grassme, K.S., Hubert, M., Guenther, S., Belting, H.G., Affolter, M., Adams, R.H., Vanhollebeke, B., Herzog, W. (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nature communications. 9:4860
- Rasmussen, J.P., Vo, N.T., Sagasti, A. (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Developmental Cell. 46(3):344-359.e4
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