Gene
steap3
- ID
- ZDB-GENE-081104-268
- Name
- STEAP family member 3, metalloreductase
- Symbol
- steap3 Nomenclature History
- Previous Names
-
- si:ch73-250a16.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cupric reductase activity and ferric-chelate reductase (NADPH) activity. Predicted to be involved in copper ion import. Predicted to act upstream of or within iron ion homeostasis and monoatomic ion transport. Predicted to be located in endosome membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP3 (STEAP3 metalloreductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypochromic microcytic anemia | Alliance | ?Anemia, hypochromic microcytic, with iron overload 2 | 615234 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ferric reductase transmembrane component-like domain | NAD(P)-binding domain superfamily | Pyrroline-5-carboxylate reductase, catalytic, N-terminal | STEAP family metalloreductases |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RHF3
|
481 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
steap3-201
(1)
|
Ensembl | 2,155 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250A16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002663293 (1) | 1692 nt | ||
| Genomic | GenBank:CU463316 (1) | 96317 nt | ||
| Polypeptide | UniProtKB:A0A8M1RHF3 (1) | 481 aa |
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Wu, J., Yang, Y., He, Y., Li, Q., Wang, X., Sun, C., Wang, L., An, Y., Luo, F. (2019) EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway. Human genomics. 13:63
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Long, Y., Yan, J., Song, G., Li, X., Li, X., Li, Q., Cui, Z. (2015) Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. BMC Genomics. 16:385
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