Gene

rnf216

ID

ZDB-GENE-081104-199

Name

ring finger protein 216

Symbol

rnf216 Nomenclature History

Previous Names

si:ch211-255l18.3

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Involved in camera-type eye development and cerebellum development. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Margolin et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnf216 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Gordon Holmes syndrome	Alliance	Cerebellar ataxia and hypogonadotropic hypogonadism	212840

Associated With rnf216 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR044066	TRIAD supradomain
Domain	IPR047544	E3 ubiquitin-protein ligase RNF216, RING finger, HC subclass
Domain	IPR047545	E3 ubiquitin-protein ligase RNF216, BRcat domain
Domain	IPR047546	E3 ubiquitin-protein ligase RNF216, Rcat domain
Family	IPR051628	Linear Ubiquitination-Associated E3 Ligases
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Length	E3 ubiquitin-protein ligase RNF216, BRcat domain	E3 ubiquitin-protein ligase RNF216, Rcat domain	E3 ubiquitin-protein ligase RNF216, RING finger, HC subclass	Linear Ubiquitination-Associated E3 Ligases	TRIAD supradomain	Zinc finger, RING/FYVE/PHD-type
UniProtKB:E7F859 InterPro	834

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rnf216-201 (1) Ensembl	Ensembl	2,927 nt	Select Tool
mRNA	rnf216-202 (1) Ensembl	Ensembl	7,522 nt	Select Tool ZFIN BLAST
mRNA	rnf216-203 (1) Ensembl	Ensembl	2,490 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations