Gene
gabrp
- ID
- ZDB-GENE-081028-62
- Name
- gamma-aminobutyric acid type A receptor subunit pi
- Symbol
- gabrp Nomenclature History
- Previous Names
-
- si:ch211-232m8.5
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable neurotransmitter receptor activity. Predicted to contribute to GABA-A receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; eye; and midbrain. Orthologous to human GABRP (gamma-aminobutyric acid type A receptor subunit pi).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42422 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
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Domain Details Per Protein
| Protein | Length | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QPJ3
|
464 | ||||||||
|
UniProtKB:A0A8M9Q4W7
|
445 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232M8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173293 (1) | 1670 nt | ||
| Genomic | GenBank:BX248097 (1) | 171333 nt | ||
| Polypeptide | UniProtKB:A0A8M9QPJ3 (1) | 464 aa |
- Bampali, K., Koniuszewski, F., Vogel, F.D., Fabjan, J., Andronis, C., Lekka, E., Virvillis, V., Seidel, T., Delaunois, A., Royer, L., Rolf, M.G., Giuliano, C., Traebert, M., Roussignol, G., Fric-Bordat, M., Mazelin-Winum, L., Bryant, S.D., Langer, T., Ernst, M. (2023) GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell biology and toxicology. 39(6):2793-2819
- Sadamitsu, K., Shigemitsu, L., Suzuki, M., Ito, D., Kashima, M., Hirata, H. (2021) Characterization of zebrafish GABAA receptor subunits. Scientific Reports. 11:6242
- Monesson-Olson, B., McClain, J.J., Case, A.E., Dorman, H.E., Turkewitz, D.R., Steiner, A.B., Downes, G.B. (2018) Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. PLoS One. 13:e0196083
- Cocco, A., Carolina Rönnberg, A.M., Jin, Z., André, G.I., Vossen, L.E., Bhandage, A.K., Thörnqvist, P.O., Birnir, B., Winberg, S. (2017) Characterisation of the γ-aminobutyric acid signalling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription quantitative polymerase chain reaction. Neuroscience. 343:300-321
- Raftery, T.D., Volz, D.C. (2015) Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos. Neurotoxicology and teratology. 49:10-8
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